Abstract
Ferulic acid (FA) is a dietary phytochemical formed during the metabolism of phenylalanine and tyrosine.Disruption of mitochondria and free radical mediated tissue injury has been reported during liver toxicity induced by carbon tetrachloride, potent hepatotoxic agent. The present study was designed to investigate the antioxidant protective effect of ferulic acid on hepatocytes, liver function and mitochondrial electron respiratory chain enzymes in hepatotoxic rats. Rats were classified into four groups : normal control group, hepatotoxic group subcutaneously injected with CCl4 once weekly for 4 weeks; thirdgroup: hepatotoxic group daily administered orally FA with a dose of 20 mg/Kg b.wt., and forth group: hepatotoxic group daily administered orally FA with a dose of 80 mg/Kg b.wt. The model of CCl 4-injected hepatocellular rats elicited declines in liver antioxidant enzyme activities; glutathione peroxidase, superoxide dismutase , Catalase in association of a reduction in reduced glutathione, serum total protein with concomitant
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