Abstract
Acridocarpus orientalis (AO) is a traditional medicinal plant used for treatment of inflammatory diseases that may have potential in cancer treatment. In the present study, the aqueous ethanolic crude extract of Acridocarpus aerial parts obtained from Al Ain and Oman were evaluated for their antioxidant capability, polyphenolic content, anti-lipoxygenase and anti-histone deacetylase (HDAC) properties. The total antioxidant capacity was estimated by the FRAP, DPPH, ABTS and β-carotene bleaching assays. Acridocarpus-Al Ain exhibited the highest polyphenolic content (184.24 mg gallic acid/g) and the best antioxidant activity (1.1, 1.04, 1.14 mmol ascorbic acid equivalent/g in the FRAP, ABTS and DPPH assays, respectively). Additionally, the same extract showed significant anti-inflammatory properties via lipoxygenase (LOX) inhibitory activity (IC50 = 50.58 µg/mL). Acridocarpus-Al Ain also showed the strongest histone deacetylase (HDACs) inhibitory activity (IC50 = 93.28 µg/mL). The results reported here suggest that there was a significant influence of location and the plant may be considered a good source of compounds with antioxidant, anti-LOX and HDAC properties for therapeutic, nutraceutical and functional food applications.
Highlights
Many plant species represent a large source of structurally new compounds that might serve as leads for the development of new drugs, nutraceuticals and functional foods
The results reported here suggest that there was a significant influence of location and the plant may be considered a good source of compounds with antioxidant, anti-LOX and histone deacetylase (HDAC) properties for therapeutic, nutraceutical and functional food applications
The ferric reducing antioxidant power (FRAP), ABTS, DPPH and β-carotene assays were used to test the antioxidant activities of Acridocarpus orientalis extracts
Summary
Many plant species represent a large source of structurally new compounds that might serve as leads for the development of new drugs, nutraceuticals and functional foods. Reactive oxygen species (ROS) induce oxidative damage to biomolecules like lipids, nucleic acids, proteins and carbohydrates This damage causes the onset of many diseases such as rheumatoid arthritis, cirrhosis, arteriosclerosis, diabetes and cancer [3]. LOX is involved in provoking several inflammation-related diseases such as arthritis, asthma, cardiovascular, cancer and allergic diseases [4,5] For this reason, targeting inhibitors of LOX is a promising therapeutic target for treating wide spectrum of human diseases. HDAC inhibitors (HDACI) represent a novel class of targeted drugs which alter the acetylation statues of several proteins These agents, modulating both chromatin structure through histone acetylation, and the activity of several non-histone substrates, are able to determine changes in gene transcription and to induce a plethora of biological effects ranging from cell death induction, to angiogenesis inhibition or modulation of immune responses [7]. HDAC inhibition activity of Acridocarpus extracts was measured with a HDAC Colorimetric Assay Kit (Millipore Corporation)
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