Abstract
The present study was designed to evaluate the cardioprotective effect of sesamol against doxorubicin-induced cardiomyopathy in rats. In this study, the cardioprotective effect of sesamol against doxorubicin induced cardiomyopathy in experimental rats was evaluated at the dosage of 50 mg/kg bw. Doxorubicin was administered to rats at a total cumulative dose of 15 mg/kg through intraperitoneal route for 2 weeks in six-divided dose on 8th, 10th, 14th, 16th, 18th, and 21st day. After the last dose administration, the endogenous antioxidants and lipid peroxidation were estimated in heart tissue homogenate. Cardiac biomarkers such as troponin T, LDH, CK, and AST and lipid profiles such as cholesterol, triglycerides, HDL, LDL, and VLDL were estimated in serum. Sesamol has cardioprotective activity through normalization of doxorubicin-induced-altered biochemical parameters. Biochemical study was further supported by histopathological study, which shows that sesamol offered myocardial protection from necrotic damage. From these findings, it has been concluded that the sesamol has significant cardioprotection against doxorubicin induced cardiomyopathy via amelioration of oxidative stress, lipid lowering, and membrane stabilization effect.
Highlights
Doxorubicin (DOX) is one of the most efficient anticancer antibiotics
There was no significant fall in the heart weight : body weight ratio in sesamol alone (G2) and sesamol+DOX (G4) treated groups compared to Group 3 (G3) (Figure 1)
There was no significant difference in the level of total cholesterol (TCH), TGL, low density lipoprotein (LDL), very low density lipoprotein (VLDL) and high density lipoprotein (HDL) in sesamol treated group (G2) when compared to control group (G1)
Summary
Doxorubicin (DOX) is one of the most efficient anticancer antibiotics. The clinical use of DOX is limited due to the extensive adverse effects. Chronic administration of DOX to cancer patients causes dose-dependent cardiotoxicity which leads to heart failure and cardiomyopathy [1, 2]. It is reported that 41% of cancer patients who received DOX are affected with various cardiac problem. DOX treatment increases the morbidity and mortality of cancer patients due to the heart failure [3]. DOX-induced cardiomyopathy is strongly linked to an increase in cardiac oxidative stress, as indicated by the depletion of endogenous antioxidant enzymes, and accumulation of free radicals in the myocardium which increases the chance of DOX-induced cardiomyopathy [4]. Higher mortality through abnormal cardiac activity limited the ability of protective role of these therapies [2]. Administration of antioxidant drugs to protect the heart from free radical damage getting more attention in cardiovascular disease research [1]
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