Abstract
Abstract Flavonoids and phenolic acids are currently believed to exert cardioprotective effects in humans via their ability to inhibit oxidation of low-density lipoprotein (LDL). The influence of chemical structure on antioxidant activity of catechin, quercetin, cyanidin, caffeic acid, and ellagic acid was evaluated by measuring inhibition of copper-catalysed human LDL oxidation in vitro . The five plant phenols investigated all possess a similar o -dihydroxy moiety. The order of antioxidant activity was catechin > cyanidin ≈ caffeic acid > quercetin > ellagic acid. The observed differences in activities are discussed in terms of structural dissimilarities of the compounds. Potential synergistic or antagonistic effects between catechin, cyanidin, caffeic acid, quercetin, and ellagic acid were investigated by measuring the antioxidant activities on LDL of 20 different combinations of two/three of these phenols. All the antioxidant effects were additive except for combinations including ellagic acid with catechin, where ellagic acid exerted a significant antagonistic effect. It is proposed that the mechanism behind this antagonistic interaction is due to hydrogen bonding between carbonyls in ellagic acid and o -dihydroxyl groups in catechin.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
