Abstract
Antioxidant Efficacy of Ananas Comosus Extract Against Renal Injury Induced by Sodium Oxalate in Rats
Highlights
Free radicals are extremely reactive species that initiate a series of harmful reactions in the cell
The purpose of the present study is to evaluate the in vivo antioxidative capacity of the extract of one of the most important fruits (Ananas comosus) against reactive oxygen species (ROSs) induced by sodium oxalate (NaOx)
Thereby, the present study demonstrated that Ananas comosus fruit extract (ACFE) administration reduced the ROSs by decreasing the lipid peroxide (LPO) level and increasing the level of AOX substances such as GSH, glutathione- S- Transferase (GST), superoxide dismutase (SOD), and CAT
Summary
Free radicals are extremely reactive species that initiate a series of harmful reactions in the cell. The balance between the production of reactive oxygen species (ROSs) and antioxidants (AOX) is vital in a biological system to eliminate the adverse effects of oxidative stress [1]. Increased production of ROSs and/ or reduced antioxidant systems rather than decreased efficiency in repairing the balance between both linked to several diseases. Reactive oxygen species play an important role in the genesis of calcium oxalate stone through free radical generation that eventually lead to lipid peroxidation causing renal injury [2,3]. Most of the ROSs is short lived and does not travel long distances and the generated free radical interacts rapidly with lipids, amino acids, proteins, carbohydrates and nucleic acids causing severe injury [6]
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