Antioxidant Effects of Guishe Extract from Agave lechuguilla on Kidney Mitochondria from Stz‐Induced Diabetic Male Rats

Abstract

Guishe from Agave lechuguilla was used to test the capacity to mitigate the oxidative stress in kidney mitochondria from streptozotocin‐induced diabetic rats. Orally, a crude aqueous extract from lyophilized guishe was administered over 5 weeks at different doses (150, 300 y 600 mg/kg). Blood glucose and body weight were monitored. The activity of catalase, thiobarbituric acid reactive species, mitochondrial superoxide dismutase, glutathione and glutathione peroxidase were determined in isolated kidney mitochondria. Our results show that guishe extracts regulates the oxidative stress observed in isolated kidney mitochondria. In conclusion, we found that guishe at doses of 300 mg/kg of body weight has a beneficial effect as an antioxidant and can be used to mitigate the oxidative stress occurring during diabetes.