Abstract
This study aimed to determine the effect of antioxidants in Gude bean (Cajanus cajan) treatment on HOMA-IR level and IRS-1 gene expression on the rats induced with high fat and high fructose diet. This study used 25 male white rats (Rattus norvegicus) in two control groups and three treatment groups. The measurement of HOMA-IR was done before and after treatment using the blood plasma while IRS-1 measurement was after treatment using the muscle tissue. The results showed that rat blood glucose level after being induced high fat and high fructose diet reached average value higher (p<0.05) compared to the Normal group. The Gude bean treatment resulted the decrease of HOMA-IR level (p<0.05) and the increase of IRS-1 (p<0.05). Gude bean treatment can inhibit insulin signal interference by ROS synthesis inhabitation by decreasing HOMA-IR level and increase IRS-1 gene expression in rats induced high fat and fructose diet.
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