Antioxidant effect of myricetin in animal model of type 2 diabetes

Abstract

Hyperglycemia increases oxidative stress which contributes to the development of diabetic complications. Myricetin has been reported to show antioxidant activity in vitro. The purpose of this study was to investigate the antioxidant effect of myricetin in animal model of type 2 diabetes. Four‐week‐old male db/db mice were fed AIN‐93G diet or diet containing myricetin (150 mg/kg) for 7 weeks after one week of adaptation. The animals were sacrificed after an overnight‐fast. Thiobarbituric acid reactive substances (TBARS) levels of the liver were measured. Activities of hepatic antioxidant enzymes were measured. Hepatic TBARS levels were significantly reduced by consumption of myricetin in db/db mice. Activities of superoxide dismutase (SOD) and catalase of myricetin group were significantly higher than those of the control group (p<0.05). Consumption of myricetin significantly increased glutathione peroxidase (GSH‐Px) activities compared with the control group. These results indicate that myricetin exerts antioxidant effect in db/db mice, suggesting it could be useful in preventing diabetic complications. This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2012015763).