Abstract
The use of nontoxic, biocompatible and very stable surfactants in the design and preparation of nanoformulations for drug delivery and food industry applications is a quickly expanding area. In this framework, Pluronics are a well explored class of triblock copolymers presenting hydrophilic poly(ethylene oxide) (PEO) and hydrophobic poly(propylene oxide) (PPO) in an A-B-A structure (PEO-PPO-PEO) with different PEO/PPO unit ratio. However, polyethers can undergo oxidation with unpredicted concerns. We describe here the design and characterization, in physiological conditions at 37 °C, of mixed formulations of Pluronic F98 or F108 with 5 or 10% of cardanol (or tert-butyl cardanol), a natural antioxidant that is able to significantly reduce (up to 80%) the detrimental peroxidation. A systematic study will be necessary to fully address the toxicity of these nanosystems but our preliminary MTT assays on fibroblasts are in favour of their benign nature.
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