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Abstract
Marine oligopeptide preparation (MOP) obtained from Chum Salmon (Oncorhynchus keta) by the method of enzymatic hydrolysis, has been found to possess a radioprotective property through stimulation of the radiation-induced immunosuppression. The current study aimed to further investigate the free radicals scavenging and antioxidant effects of MOP in radiation injured mice. Female ICR mice (6–8 weeks old) were randomly divided into 5 groups, i.e., blank control, irradiation control and MOP (0.225, 0.450 and 1.350 g/kg body weight) plus an irradiation-treated group. The result revealed that MOP significantly increased the white blood cell counts after irradiation, and lessened the radiation-induced oxidative damage. These effects may be caused by augmentation of the activities of antioxidant enzymes, such as SOD and GSH-Px, reduction of the lipid peroxidation (MDA level) in liver, and protection against radiation-induced apoptosis. Therefore, we propose that MOP be used as an ideal antioxidant to alleviate radiation-induced oxidation damage in cancer patients.
Highlights
In recent years it has been increasingly acknowledged that dietary proteins provide a rich source of bioactive peptides that can promote human health by reducing the risk of chronic diseases [1,2,3].Similar to various endogenous bioactive peptides, such as some hormones, bioactive peptides from dietary sources have been defined as specific protein fragments that have a positive impact on body functions or conditions, and that may eventually benefit health
Our earlier research demonstrated that marine oligopeptide preparation (MOP), compounds of low molecule peptides extracted from salmon minced meat by enzymatic hydrolysis, possess a radioprotective property through stimulation of the radiation-induced immunosuppression, and may have a supplementary protective effect in cancer therapy [13]
After HPLC purity and MALDI-TOF-MS analysis, we found that the molecular weight distribution of Marine oligopeptide preparation (MOP) was between 100 and 860 Da, and most of the peptides were distributed between 300 and
Summary
In recent years it has been increasingly acknowledged that dietary proteins provide a rich source of bioactive peptides that can promote human health by reducing the risk of chronic diseases [1,2,3]. Bones, scales and residual minced meat, the by-products of the fish-processing industry, which usually cause wastage and pollution, can be turned into a high-protein food [5,6]. It has been found that enzymatic hydrolysis of dietary proteins offers a rapid and reproducible method for producing considerable bioactive peptide fractions, which are very likely to become health-beneficial food ingredients or nutraceutical preparations [7]. Our earlier research demonstrated that marine oligopeptide preparation (MOP), compounds of low molecule peptides extracted from salmon minced meat by enzymatic hydrolysis, possess a radioprotective property through stimulation of the radiation-induced immunosuppression, and may have a supplementary protective effect in cancer therapy [13]. The present study reported here mainly focuses on the free radicals scavenging and antioxidant effects of MOP in radiation injured mice
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