Antioxidant defense in cotton under environmental stresses: Unraveling the crucial role of a universal defense regulator for enhanced cotton sustainability

Abstract

Cotton (Gossypium spp.) is a globally significant crop that provides natural fibers for the textile industry and also an important oil and biopharmaceutical resources. However, the production of cotton faces substantial challenges due to various biotic and abiotic stress factors that can negatively impact cotton growth, yield, and fiber quality. This review offers a comprehensive overview of the effects of biotic stress factors, such as insect pests, bacterial, fungal, and viral pathogens, and nematodes, as well as abiotic stress factors, including extreme hot and cold temperature, drought, toxicity induced by heavy metal and salinity, on the antioxidant systems in cotton. We discuss the crucial antioxidants, such as glutathione, proline, and phenolics, and highlight major antioxidant enzymes, including ascorbate peroxidase (APX), superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), and glutathione reductase (GR), and their roles in cotton's response to these stress factors. Furthermore, we explore the potential mechanisms and the crosstalk between different stress factors signaling pathways. We also examine the implications of stress-induced changes in antioxidant levels and enzyme activities for cotton productivity and breeding strategies. Additionally, we shed light on the unanswered questions, research gaps, and future perspectives in this field, paving the way for further investigations to enhance our understanding of cotton's antioxidant defenses and develop novel strategies for improving cotton stress tolerance and yield stability.