Antioxidant defence system in a patient with cerebrovascular accident.

Abstract

The increased production of reactive oxygen metabolites in the central nervous system may result in cellular damage and vascular-parenchymal injury. Vascular injury is also a cause of the vasoregulation deficiency. In this case report, a 60-year-old woman was admitted to the department of neurology, with a diagnosis of cerebrovascular accident. During 18 days of follow-up, the status of the antioxidant system was determined by measuring red cell superoxide dismutase and catalase activity. Red cell and plasma copper, zinc and magnesium concentrations were also measured. Red cell superoxide dismutase activity increased markedly by Day 2, reached a peak on Day 6 before decreasing to normal 18 days after the injury. Red cell catalase activity was below normal values during the whole of the 18-day study period and was at its lowest between days 6 and 7. Plasma copper, zinc and magnesium concentrations showed corresponding alterations.