Abstract
BackgroundAntioxidants located in both the hydrophilic and lipophilic compartments of plasma act as a defence system against reactive oxygen species (ROS). Excessive production of ROS during anaesthesia affects the antioxidant capacity of plasma and may result in oxidative stress. The aim of this study was to evaluate the antioxidant capacity of lipid- (ACL) and water-soluble (ACW) antioxidants in client-owned dogs diagnosed with periodontal disease and early-stage myxomatous mitral valve degeneration (MMVD) and anaesthetised for a dental procedure with propofol and sevoflurane or with propofol only.ResultsDogs with MMVD were anaesthetised with propofol and sevoflurane (MMVD/PS, n = 8) or with propofol only (MMVD/P, n = 10). Dogs with no evidence of MMVD (PS, n = 12) were anaesthetised with propofol and sevoflurane. Blood samples for determination of ACL and ACW were collected before and 5 min, 60 min and 6 h after induction to anaesthesia. In MMVD/PS dogs, ACL was significantly higher at all sampling times when compared to PS dogs. Compared to basal values, only anaesthesia maintained with propofol significantly increased ACL at 60 min in dogs with MMVD. In MMVD/P dogs, ACW increased after induction to anaesthesia and remained elevated up to 6 h after anaesthesia. Compared to basal values, anaesthesia maintained with sevoflurane significantly increased ACW only at 60 min in both dogs with and without MMVD. The only difference between propofol and propofol/sevoflurane anaesthesia in dogs with MMVD was significantly higher ACW at 60 min after induction to anaesthesia in the propofol group.ConclusionsRegarding antioxidant capacity, propofol could be a better choice than sevoflurane for anaesthesia of dogs with early-stage MMVD, although further studies are necessary to clarify the advantage of this antioxidant capacity.
Highlights
Antioxidants located in both the hydrophilic and lipophilic compartments of plasma act as a defence system against reactive oxygen species (ROS)
Eighteen dogs diagnosed with myxomatous mitral valve degeneration (MMVD) American College of Veterinary Internal Medicine (ACVIM) class B1 and B2, 7 females (3 neutered, 4 intact) and 11 males (3 neutered, 8 intact), weighing 17.52 ± 8.86 kg and aged 8.65 ± 3.05 years were included in the study
Some samples for determination of Antioxidant capacity of water-soluble antioxidants (ACW) were excluded from the study due to technical problems with latent fibrin formation and the results are reported only for 7 dogs in the MMVD/PS group, 10 dogs in the PS group and 8 dogs in the dogs with MMVD and anaesthetised with propofol (MMVD/P) group
Summary
Antioxidants located in both the hydrophilic and lipophilic compartments of plasma act as a defence system against reactive oxygen species (ROS). Excessive production of ROS during anaesthesia affects the antioxidant capacity of plasma and may result in oxidative stress. The heart is constantly subjected to ROS formation due to the high rate of aerobic metabolism [1]. Antioxidants located in both the hydrophilic and lipophilic compartments of plasma are actively involved in a defence system against ROS [2]. The metabolism of anaesthetics and changes in tissue oxygenation increase formation of ROS [7, 8] and induce cardiac injury [7, 9] by aggravating oxidative stress [1]. Sevoflurane, on the other hand, may promote ROS formation through its metabolism [12] and by influencing mitochondrial function [13]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
