Abstract
The aims of this study were to quantify the phenolic content and evaluate the antioxidant potential of extracts from the bark and leaves of C. pyramidalis and S. glandulosum. The total phenolic content (TPC) and total tannin content (TTC) were determined using the Folin-Ciocalteu method, and the total flavonoids content (TFC) was measured via complexation with aluminum chloride. The antioxidant activity was evaluated with DPPH (2.2-diphenyl-1-picrylhydrazyl) and FIC (ferrous ion chelating) assays. The TPC ranged between 135.55 ± 9.85 and 459.79 ± 11.65 tannic acid equivalents (TAE) in mg/g material (mg TAE/g). The leaves of both species contained high levels of tannins and flavonoids. The crude ethanol extracts (CEE) from the bark of C. pyramidalis showed high antioxidant activity when compared to ascorbic acid and rutin, whereas the CEE from the leaves was more efficient in chelating ferrous ions. C. pyramidalis had very high phenolic content and anti-radical activity, which indicates a need for further studies aimed at the purification and identification of compounds responsible for the antioxidant activity.
Highlights
In Brazil, several research groups have evaluated the diversity of the medicinal species from different biomes
Given the therapeutic potential of these plants, the objectives of this paper were to evaluate the content of phenolic compounds, including total phenolic content (TPC), total tannin content (TTC), and total flavanoid content (TFC) and the antioxidant activity (DPPH and FIC assay) of crude ethanol extracts of the bark and leaves of C. pyramidalis and S. glandulosum
Our results showed that the crude ethanol extracts (CEE) of the bark of C. pyramidalis has high radical scavenging capacity and can be used to inhibit the oxidation of vital substances by reactive oxygen species, possibly by acting as a primary antioxidant
Summary
In Brazil, several research groups have evaluated the diversity of the medicinal species from different biomes. From C. pyramidalis was reported, but to the best of our knowledge, no chemical profile of the specie S. glandulosum has been published Based on their traditional uses in folk medicine, several thematic groups have been consolidated and form the basis of new fields, such as ethnopharmacology, that focus on gathering knowledge about the natural resources used in traditional folk medicine [8,9]. Among the various questions investigated in this field, the potential reduction of the time needed for the discovery of new drugs to treat diseases that already have alternative therapies or for those disease without known treatments is the most promising. Given the therapeutic potential of these plants, the objectives of this paper were to evaluate the content of phenolic compounds, including total phenolic content (TPC), total tannin content (TTC), and total flavanoid content (TFC) and the antioxidant activity (DPPH and FIC assay) of crude ethanol extracts of the bark and leaves of C. pyramidalis and S. glandulosum
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