Antioxidant capacities in adenoma polyp patients after dietary intervention with antioxidant‐rich foods

Abstract

Intakes of high fiber, fruits and vegetables and low fat have been suggested to have protective effect on colorectal adenoma and cancer. This study was carried out by supplementing antioxidant-rich foods to enhance the antioxidant capacities of the colorectal adenoma patients. A total of 38 patients (aged 35 to 74) were provided with dietary supplement of 1 bowl of sprouted rice porridge (D.W. F&B) and 2 cans of mixed vegetable juice (N.S. Co., Ltd.,) daily for 12 weeks. The plasma concentrations of antioxidant vitamins; β-carotene (24.8±1.86 vs 28.4±1.77 μg/dL, p<0.02), lutein (8.72±0.97 vs 9.91±1.13 μg/dL, p<0.003), lycopene (7.56±0.54 vs 8.66±0.62 μg/dL, p<0.002) increased significantly after the intervention. The serum levels of antioxidant minerals; Se (7.28±0.56 vs 8.52±0.63 μg/dL, p<0.008) and Zn (89.3±3.64 vs 97.7±3.62 μg/dL, p<0.03) were increased, the Cu/Zn ratio (1.12±0.05 vs 1.05±0.04, p<0.03) showed a significant decrease. Serum folate level (8.1±0.65 vs 9.2±0.79 ng/mL, p<0.05) and the folate/homocysteine ratio (0.92±0.09 vs 1.11±0.12, p<0.02) were also significantly elevated. In addition, the serum TG level significantly dropped (153.9 ±11.5 vs 133.1±8.8 mg/dL, p<0.05) at the end of the study. This study supports the possibility of improving antioxidant capacities of adenoma polyp patients with antioxidant-rich supplement foods for a relatively short period of time. Supported by the Korea Science & Engineering Foundation, Nong Shim Co., Ltd., and Dong Won F&B.