Abstract

Uric acid is a naturally occurring antioxidant that is produced in the body as a byproduct of the enzymatic breakdown of xanthine. Inflammation of the blood vessel cells in the human body can be brought on by abnormally high amounts of uric acid in the serum. An acute inflammatory response often manifests with symptoms similar to those of gout attacks. XO is a major contributor to the production of superoxide free radicals, which are a factor in chronic inflammatory diseases. Existing drugs have been used to treat gout and inflammatory diseases, but have negative effects in humans. Medicinal plants are a source of active chemicals, which are particularly significant in the process of developing new medications due to the variety and distinctive chemical structures of these active compounds. Justicia gendarussa, Andrographis paniculata (Burn.f.) Nees, Ruellia tuberosa L, and Clinacanthus nutans Lindau are examples of plant species in the Acanthaceae family. The results of existing publications show that the bioactive compounds contained in these plants have a relationship between antioxidant activity, anti-uric acid and anti-inflammatory properties.

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