Antioxidant, anticancer, antibacterial activities and GCMS analysis of aqueous extract of pulps of Aegle marmelos (L.) Correa

Abstract

Aegle marmelos (Bael) is an important medicinal plant which belongs to family Rutaceae. Leaves, fruit, stem, bark of this plant is used because of its medicinal properties like astringent, antidiarrheal, antipyretic, antiinflammatory activities. Compounds purified from A.marmelos have been proven biologically active against various several major diseases like cancer, diabetes, cardiovascular diseases. The aim of the present study was to evaluate the antioxidant, anticancer and antibacterial activities of aqueous extract of A. marmelos and to identify the bioactive compounds by GC-MS analysis. Antioxidant activities such as DPPH radical, ABTS·+ radical cation, Fe3+ reducing power and phosphomolybdenum reduction assays were carried out for aqueous extract. The maximum DPPH radical and ABTS·+ radical cation scavenging activities were 60.70±4.24% at 300 µg/mL and 95.77±6.70% at 30 µg/mL concentrations. The IC50 values of DPPH˙ radical and ABTS·+ radical cation scavenging activities were 183.58 µg/mL and 10.81 µg/mL concentration. The maximum reduction of Fe3+ and Mo6+ were 52.05±3.64% and 87.81±6.19% at 120 µg/mL concentration and the IC50 values were 102.83 µg/mL and 32.76 µg/mL concentration. The anticancer activity was carried out by MTT assay method, which showed the IC50 value of 47.92 µg/mL concentration.