Abstract
Deep eutectic solvents as a new type of eco-friendly solvents have attracted attention in chemistry, medicine, and other fields for the extraction and separation of target compounds from medicinal plants. Deep eutectic solvents are easy to prepare and have many advantages as solvents, such as chemical inertness with water, low cost, easy biodegradability, and pharmaceutically acceptable toxicity. In this study, a deep eutectic solvent made up of choline chloride-glycerol (1:2) was used for the extraction of flavonoids from Catharanthus roseus plant parts (flower petal, leaves, stem, and root). The highest amount of phenolic content was detected in flower petal, that is, 194.50 mg GAE/g. In DPPH test, the maximum amount of antioxidant activity determined in the flower petal was 73.13%; IC50 was calculated by using a linear regression equation; IC50 value of the standard, stem, root, leaf, and flower petal was 13.22, 90.44, 83.93, 120.14, 79.49 μg/ml, respectively. The result of this research is that Catharanthus roseus has a compatible antioxidant activity. This can be helpful for the treatment of diseases caused by free-radical oxidative stress.
Highlights
Plants are the essential foundation of medicine [1]
Due to the presence of free radical scavenger an odd electron rabm.scholasticahq.com gets combined with an antioxidant agent, DPPH radicals get concentrated to corresponding hydrazine, DPPH-H form, and the sample solution changes from deep violet to light yellow color
In Catharanthus roseus plant parts, the IC50 value of root is 83.93 μg/ml, and IC50 value of stem is 90.44 μg/ml, whereas leaves have IC50 120.14 μg/ml and flower petal 79.49 μg/ml, which indicated that flower petal has more antioxidant activity than root and little bit low in stem and lowest antioxidant activity in leaves
Summary
Plants are the essential foundation of medicine [1]. Medicinal plants are the main source of bioactive compounds. In the field of nutrition and food science, bioactive compounds have extra health benefits that promote and maintain consumers’ health and prevent chronic illnesses, which are the main topics of discussion nowadays. For the recovery of bioactive compounds from medicinal plants, solid-liquid extraction is used in numerous biochemical, chemical, and pharmaceutical industries. Medicinal plants usually have a minor quantity of active compounds; most of the time, the development of a high-performance process justifies its extraordinary value. The effective extraction of bioactive compounds from medicinal plants with great purity and without any loss of activity has resulted in the development of the new extraction process [2]
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