Abstract
Blueberry has attracted much attention due to their potential health benefits. Blueberry contains a diverse of biological properties such as antioxidant and anti‐inflammatory activities. The aim of this study is to confirm the effect of blueberry extracts on skin pores contraction through antioxidant activity, quantification of tannin contents, protein aggregation assay and inhibition of 5‐alpha‐reductase type 1 mRNA expression. Blueberry was extracted with 70% ethanol and then fractionated with hexane, CHCl3, EtOAc, BuOH and water to get active fractions. Antioxidant activity of each fraction was determined by using the DPPH and FRAP assay. All fractions had high antioxidant activities, tannin contents than crude extract, but blueberry ethyl acetate (BB‐E) fraction was at the top of the list. Protein aggregation of blueberry fraction has an effect as compared with positive control tannic acid. The major factor contributing to excess sebum is 5‐alpha reductase type1 which related to enlarge skin pores. We confirmed that blueberry fractions reduced 5‐alpha reductase type1 expression in HaCaT using RT‐PCR method. In conclusion, we expected the beneficial effect of blueberry on skin pores contraction.Grant Funding Source : Ipeeres Ltd.
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