Abstract
This study is aimed to elucidate the possible antioxidant and protective effects of Artemisia campestris essential oil (ACEO) against the deleterious effects of chlorpyrifos (CPF) in rats. The in vivo study revealed increases in aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), and alkaline phosphatase (ALP) activities and the serum contents of creatinine, urea, uric acid, cholesterol, triglycerides, low density lipoproteins (LDL), and glucose in rats treated with CPF as compared to controls. Meanwhile, hepatic and renal activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in liver and kidney decreased and the content of malondialdehyde (MDA) increased. Some histopathologic features were noticed in liver and kidney of the CPF group. Interestingly, ACEO alleviated the biochemical disruptions and reduced these hepato-renal morphologic changes.
Highlights
Pesticides are commonly used to control insects, fungal diseases, and weeds to protect the world’s food supply
Significant decreases in the levels of serum AST, ALT, alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) in Artemisia campestris essential oil (ACEO) plus CPF (ACEO + CPF) rats (3.59, 9.42, 24.9, and Parameters and treatments Food intake (g/rat/d) Gain weights (%)
Rats exposed to CPF exhibited increases of serum AST, ALT, ALP, and LDH activities, which could be a consequence of hepatic tissues injury
Summary
Pesticides are commonly used to control insects, fungal diseases, and weeds to protect the world’s food supply. Humans are differently exposed to pesticides; either directly in agricultural occupations or indirectly through the consumption of contaminated food (Badraoui et al, 2007; Negatu et al, 2016; Mzid et al, 2017) The appearance of these molecules (pesticides), generally more effective against pests than the inorganic molecules that preceded them (copper sulfate, lime.). These products have made interesting progress in the quality and quantity of crops and in the fight against disease vectors (Donkor et al, 2016). Pesticides can enter the body via the three major routes of exposure: inhalation, ingestion, and skin contact through the lungs, the mouth, and the dermal contact, respectively
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