Abstract
BackgroundIn the present study, the phenolic compounds were prepared using ultrasonic-aid extraction from sugar beet molasses (SBM).MethodsGallic acid (GA), cyanidin-3-O-glucoside chloride (CGC) and epicatechin (EP) were produced after column chromatography from the extraction, and further detected using NMR, QTOF-MS and ESI-MS/MS.ResultsThe three compounds exhibited strong antioxidant activities including DPPH radical scavenging activities, ABTS radical scavenging activities and ORAC values. GA showed the strongest antioxidant activity. Antitumor activities significantly increased in a dose-dependent manner. In particular, the CGC had growth inhibitory activities of 94.86, 87.27 and 67.13 % against the human colon (CACO-2), hepatocellular (HepG2) and breast (MCF-7) carcinoma cell lines, respectively, at the highest concentration of 400 μg/mL of the extracts. These results suggest that the three compounds are key chemical compositions valuable for preparing functional foods in the food industry.ConclusionsThe results suggested that SBM is a natural source of antioxidant and antitumor agents for preparing functional foods.
Highlights
In the present study, the phenolic compounds were prepared using ultrasonic-aid extraction from sugar beet molasses (SBM)
While recent study reported that SBM showed higher antioxidant activity, anti-inflammatory and anti-proliferative activities [6, 7], the bioactive components of SBM are mainly phenolics, alkaloids, tannins, saponins, terpenoids, steroids, and volatile oil [8], and specific bioactive compounds such as syringic acid, vanillin, ferulic acid, hydroxybenzaldehyde, hydroxybenzoic acid, luteolin/ kaempferol, feruloyl-arabinose-arabinose and caffeoyltartaric acid which have been prepared and identified [9]
Many investigations revealed that phenolic contents contribute to the antioxidant and antitumor activities of plants [15]
Summary
The phenolic compounds were prepared using ultrasonic-aid extraction from sugar beet molasses (SBM). While recent study reported that SBM showed higher antioxidant activity, anti-inflammatory and anti-proliferative activities [6, 7], the bioactive components of SBM are mainly phenolics, alkaloids, tannins, saponins, terpenoids, steroids, and volatile oil [8], and specific bioactive compounds such as syringic acid, vanillin, ferulic acid, hydroxybenzaldehyde, hydroxybenzoic acid, luteolin/ kaempferol, feruloyl-arabinose-arabinose and caffeoyltartaric acid which have been prepared and identified [9]. Many investigations revealed that phenolic contents contribute to the antioxidant and antitumor activities of plants [15]. To the best of our knowledge, there were few reports on the antioxidant and antitumor activities of phenolics from sugar beet molasses (SBMP). Given the rich natural resources of SBM, the extraction researches of SBMP will have a highly practical value
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