Antioxidant and hypercholesterolemia effects of Lagerstroemia speciosa ethanolic green and red leaf extracts against Lauric acid and ketogenic diets in female albino rats

Abstract

The study investigates the therapeutic value of Lagerstroemia speciosa ethanolic green and red leaf extracts against Lauric acid (LA) and a Ketogenic diet (KGD) in Albino rats. Lauric acid is an important constituent in breast milk, forming nutritional factors and having various medicinal values. It is present in 6.2% of human breast milk, 3.1% of goat milk, and 2.9% in cow milk. It is also found in plant sources like coconut, cohune, and palm kernel oil. The Ketogenic diet uses fat, protein, and low carbohydrate for energy. The experimental groups were fed a Ketogenic diet for 21 days, with the treated groups showing a significant increase in blood cell count and Hg levels. The phytochemical profile reveals abundant phytoconstituents, including corosolic acid, lagerstroemin, and anthocyanin, at high levels. The study compared experimental groups fed with LELE Low Dose and High Dose (250 and 500 mg/kg body weight) and standard groups treated with KGD and Lauric acid. The treated groups showed significant elevations in biochemical parameters and increased blood cells and Hg levels. LELE's anti-hypercholesterolemia activity in KGD significantly reduced body weight, total lipid profile, and blood glucose in a dose-dependent manner. The study found that LELE is safe and non-toxic, with the treated group demonstrating dose dependence and decreased obesity.