Abstract
In the present study we have evaluated the hepatoprotective efficacy of soy isoflavones (SIF), against carbon tetrachloride (CCl4) induced oxidative damage and early tumor response in male Wistar rats. Methods: Single treatment of CCl4 (1:1 v/v in corn oil was administered orally at dose of 1ml kg-1 body weight) induced oxidative stress and enhanced early tumor markers. Results: CCl4 treatment resulted in marked reduction of hepatic glutathione content and activities of hepatic anti-oxidant enzymes, viz., glutathione peroxidase (GPx), glutathione reductase (GR), catalase (CAT), glucose-6- phosphate dehydrogenase (G6PD) and phase-II metabolising enzymes such as glutathione-S-transferase (GST) and quinone reductase (QR) significantly as compared to control group (p
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