Antioxidant and hepatoprotective effects of Garcinia indica fruit rind in antitubercular drug-induced liver injury in rats

Abstract

Antioxidant and hepatoprotective effects of Garcinia indica fruit rind in antitubercular drug-induced liver injury in rats Vandana S Panda,1 Hardik D Ashar,1 Anita Sharan2 1Department of Pharmacology and Toxicology, Prin KM Kundnani College of Pharmacy, Colaba, Mumbai, India; 2Department of Pathology, Dr DY Patil Medical College, Nerul, Navi Mumbai, India Abstract: The protective effects of aqueous extracts of the fruit rind of Garcinia indica (GIE) in antitubercular drug (ATD)-induced liver injury were investigated in rats. GIE (400 mg/kg and 800 mg/kg) and the reference drug Liv.52 (500 mg/kg) were administered orally for 29 days to ATD (isoniazid 7.5 mg/kg, rifampicin 10 mg/kg, and pyrazinamide 35 mg/kg)-treated rats. GIE attenuated significantly the ATD-elevated levels of aspartate aminotransferase, alanine transaminase, alkaline phosphatase, bilirubin, and malondialdehyde and restored the ATD-depleted levels of glutathione (GSH), superoxide dismutase, catalase, GSH peroxidase, and GSH reductase. The present findings indicate that the hepatoprotective effect of GIE in ATD-induced oxidative damage may be due to its antioxidant activity. Keywords: Garcinia indica fruit, antitubercular drugs, Liv.52, hepatoprotective, antioxidant activity