Antioxidant and hepatoprotective activity of Flemingia tuberosa Dalzell in CCl4-induced hepatotoxicity in rats

doi:10.7324/japs.2020.10605

Abstract

Micro-morphology of Achillea clypeolata: contribution to the pharmacognostical profileAnely Nedelcheva

Highlights

The liver, which is a vital organ of metabolism, plays a major role in detoxification and elimination of toxicants (Saleem et al, 2018; Sultana et al, 2018)
The standardized ethanolic extract of F. tuberosa was found to be rich in kaempferol which has been reported to possess hepatoprotective in addition to antioxidant activity (Chen et al, 2018; Wang et al, 2018; Yin et al, 2018)
The results of this study indicate that the standardized ethanolic extract of the aerial parts of F. tuberosa showed a significant hepatoprotective activity at the dose of 500 mg/kg body weight

Summary

Introduction

The liver, which is a vital organ of metabolism, plays a major role in detoxification and elimination of toxicants (Saleem et al, 2018; Sultana et al, 2018). Carbon tetrachloride (CCl4), as a standout among the hepatotoxins, is generally utilized to measure the efficiency of many hepatoprotective drugs (Cheng et al, 2013; Recknagel et al, 1989; Zarezade et al, 2018; Zhao et al, 2018). Medicinal plants are great sources of natural compounds such as phenolic acids and flavonoids, which have antioxidative properties, and are able to scavenge free radicals and defend the liver from CCl4-induced hepatic injury (Azeem et al, 2010; Gnanadesigan et al, 2011; Gupta et al, 2011; Singhal and Gupta, 2012; Zarezade et al, 2018). Many plants have been reported to show the hepatoprotective activity, namely, Phaseolus trilobus (Fursule and Patil, 2010), Cassia abbreviata (Sobeh et al, 2018), Cichorium glandulosum (Tong et al, 2015), Cichorium intybus (Heibatollah et al, 2008), Parmelia perlata (Shailajan et al, 2014), Artocarpus lakoocha (Saleem et al, 2018), Avicennia marina (Joshi and Shailajan, 2016), Hibiscus vitifolius (Samuel et al, 2012), Solanum nigrum (Raju et al, 2003), Asteracantha longifolia (Shailajan et al, 2005), and Flemingia macrophylla (Hsieh et al, 2011)

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