ANTIOXIDANT AND HAEMATOLOGICAL RESPONSES OF L-ARGININE ON MONOSODIUM GLUTAMATE-INDUCED OXIDATIVE STRESS IN RATS’ SERUM

Abstract

This study aimed to examine the possible antioxidant and haematological responses of L-arginine on oxidative stress induced by monosodium glutamate burden in rats’ serum. Thus, monosodium glutamate, at a dose of 8000 mg/Kg of body weight was administered to male Wistar rats by oral intubation daily for 28 days. Monosodium glutamate treatment significantly increased malondialdehyde but diminished reduced glutathione concentrations, catalase and superoxide dismutase activities in the rats’ serum. Monosodium glutamate treatment significantly decreased haemoglobin and packed cell volume but non-significantly decreased white blood cells contents in the rats’ serum. L-arginine either mono-treatment or co-treatments with monosodium glutamate significantly decreased malondialdehyde but increased reduced glutathione concentrations catalase and superoxide dismutase activities in the rats’ serum compared to control and monosodium glutamate treatment. L-arginine either mono-treatment or co-treatments with monosodium glutamate significantly increased haemoglobin, packed cell volume and white blood cells contents compared to control and monosodium glutamate treatment. Results revealed that these effects induced by monosodium glutamate at a dose of 8000 mg/Kg in the rats’ serum were significantly mitigated by L-arginine. The antioxidant effects by L-arginine were notably significant at 120 mg/Kg in the rats’ serum and accompanied by probable up-regulation in the rats’ haematological expression and functions.