Abstract
The acetone extracts and fractions prepared from the roots of Euphorbia hylonoma were investigated for 1, 1-diphenyl-2-pycrylhydrazyl (DPPH) free radical, superoxide anion and hydroxyl radical scavenging activity and cytotoxic activity against the human hepatoma cell line SMMC-7721, human cervix epitheloid carcinoma cell line HeLa and the human gastric cancer cell line SGC-7901. The acetone extract and fraction of EtOAc showed high antioxidant activities. The acetone extract and fraction of water showed a stronger cytotoxic effect on all tested cells, with IC50 values being less than 20 μg/mL. The acetone extract and fraction of water induced cell cycle arrest in G1 phase in SMMC-7721 cells. The major compounds isolated from the acetone extract were ellagic acid derivatives and showed weak cytotoxic activities on the tested cell lines, and these compound were 3,3i‚¢,4-tri-O-methylellagic acid (1), 3,3i‚¢-di-O-methylellagic acid (2), 3-O-methylellagic acid (3) and 3,3i‚¢-di-O-methylellagic acid-4i‚¢-O-β-dxylopyranosid (4). Compound 3 showed better obvious radical scavenging activity than other tested compounds. Key words: Euphorbia hylonorma Hand-Mazz, antioxidant activity, cytotoxic activity, chemical constituents.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
