Abstract
Physalis peruviana has widely used in folk medicine as a medicinal herb for treating diseases since ancient times. It is a pharmacologically valuable natural product due to the presence of biologically active compounds such as phytosterols, vitamins, essential minerals, withanolides and physalins. In this study, we aimed to observe the antioxidant capacity and cytotoxic activity of edible parts of P. peruviana on different cancer cell lines [human colon adenocarcinoma cell line (HT-29), human prostate adenocarcinoma cell line (LNCap), human hepatoma cell line (Hep3B), human breast adenocarcinoma cell line (MCF-7), human neuroblastoma cell line (SH-SY5Y), human osteosarcoma cell line (SaOS-2)] and a non-cancerous kidney epithelial cells from African green monkey (Vero) cell line. Antioxidant activity of the fruit extracts was determined with DPPH (1,1-diphenyl-2-picrylhidrazil) radical scavenging method and cytotoxic effect was observed by using MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyltetrazolium bromide) assay. For antioxidant capacity of the crude extract, IC 50 value was calculated as 0.43±0.003 mg/ml. IC 50 values of cytotoxicity for HT-29, Hep3B, SaOS-2 and SH-SY5Ycell lines for 48 h were determined as 40.79, 24.92, 15.44 and 44.24 µg/ml, respectively. Fruit extract of P. peruviana had no cytotoxic effect on MCF-7, LNCap and Vero cell lines.
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