Antioxidant and Antiulcer property of different solvent extracts of Cassia tora Linn.

Abstract

Aim: The fundamental objective and goal of the current research is to determine the effectiveness of Cassia tora in the treatment of gastric ulcers in order to produce an anti-ulcer medication of natural origin. Method: The plant material was successively extracted by the Soxhlet extraction technique with chloroform, methanol, butanol and water. The antioxidant activity of the plant extracts and the standard drugs were based on consideration of the radical scavenging influence of the stable "1,1-diphenyl-2-picrylhydrazyl" (DPPH) free radical action and hydrogen peroxide process. Two models, and non-steroidal anti-inflammatory induced ulcer and pyloric ligation, were analysed for methanolic extract of Cassia tora for its antiulcer activity. Results: Among all the extract, the percent of DPPH inhibition at 200 μg mL-1 for MECT extracts (Cassia tora methanolic extract) was 58.67±1.95. The overall scavenging potential for the H2O2 process was 68.23±0.19 at 200 μg mL-1 by MECT extract. Hence MECT extract was undertaken for the antiulcer property. Compared with control, there was a significant (p<0.05) decrease in free acidity, gastric volume, and total acidity in the extract-treated classes and ranitidine (standard). The Cassia tora methanolic extract demonstrated significant (p<0.05) inhibition activity, i.e. 59.42 and 69.59 percent at 500 mg mL-1 with the PL (Pylorus ligation) and NSAID (Non-steroidal anti-inflammatory drugs) process respectively. Conclusion: The findings of present study provide the scientific evidence to Cassia tora as a strong antiulcer and antioxidant agent.