Abstract
Reactive oxygen species are implicated in various inflammatory disorders. Vitex negundo is mentioned in Ayurveda as useful in treating arthritic disorders. The present work was undertaken to evaluate the antioxidant potential and anti-inflammatory activity of the plant. The total methanol extract of the plant was standardized in terms of total polyphenols. The standardized extract in a dose of 100 mg/kg caused a comparable reduction in edema with that of diclofenac sodium (25 mg/kg) when evaluated for antiinflammatory activity by carrageenan-induced rat paw edema method. The extract also exhibited a strong free radical scavenging activity by 1,1-diphenyl-2-picrylhydrazyl method and caused a significant reduction in the formation of thiobarbituric acid reacting substances when evaluated for its lipid peroxidation inhibitory activity. The results strongly suggest that radical quenching may be one of the mechanisms responsible for its antiinflammatory activity.
Highlights
Reactive oxygen species are implicated in various inflammatory disorders
About 5% of the inhaled oxygen is converted to harmful reactive oxygen species like O 2, H 2 O 2, OH [2]
In many inflammatory disorders there is excess activation of phagocytes and production of superoxide (O 2 - ) radical [3] which can harm surrounding tissue either by a powerful direct oxidizing action or indirectly as with hydrogen peroxide (H 2 O 2 ) and hydroxyl radicals (OH) formed from O 2 - which initiate lipid peroxidation resulting in membrane destruction
Summary
Reactive oxygen species are implicated in various inflammatory disorders. Vitex negundo is mentioned in Ayurveda as useful in treating arthritic disorders. Antioxidant and antiinflammatory activity of Vitex negundo.Indian J Pharm Sci 2008;70:838-840 Antioxidant and antiinflammatory activity of Vitex negundo. The reactive oxygen species are known to activate matrix metalloproteinase (e.g. collagenase) causing increased destruction of http://www.ijpsonline.com/printarticle.asp?issn=0250-474X;year=2008;volume=70;issue=6;spage=838;e...
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