Abstract
The advanced glycation end-products (AGEs) arise from non-enzymatic reactions of sugar with protein side chains, some of which are oxido-reductive in nature. Enhanced production of AGEs plays an important role in the pathogenesis of diabetic complications as well as in natural aging, renal failure, oxidative stress, and chronic inflammation. The aim of this work is to study antiglycation effects of polyphenol compounds extracted by hazelnut skin that represents an example of polyphenols-rich food industry by-product, on AGEs formation. AGEs derived from incubation of bovine serum albumin (BSA) and methylglyoxal (MGO) were characterized by fluorescence. The phenolics identification and total polyphenol content in hazelnut skin extracts were analyzed by HPLC-MS and the Folin–Ciocalteu method, respectively. Antioxidant efficacy was evaluated by monitoring total antioxidant activity to assess the ABTS radical scavenging activity of samples by TEAC assay and oxygen radical absorbance capacity (ORAC) assay, expressed as millimoles of Trolox equivalents per gram of sample. Data here presented suggest that phenolic compounds in hazelnut skin have an inhibitory effect on the BSA-AGEs model in vitro, and this effect is concentration-dependent. The putative role of the hazelnut skin antioxidative properties for hindering AGEs formation is also discussed. Because of AGEs contribution to the pathogenesis of several chronic diseases, foods enriched, or supplements containing natural bioactive molecules able to inhibit their production could be an interesting new strategy for supporting therapeutic approaches with a positive effect on human health.
Highlights
Nowadays, the positive correlation between consumption of plant food rich in bioactive components and good health is well known
The present study aims to investigate the inhibitory effects on advanced glycation end-products (AGEs) formation of extracts from hazelnut skin
We have proven that thephenolic extract of hazelnut skins can reduce formation of AGEs in vitro
Summary
The positive correlation between consumption of plant food rich in bioactive components and good health is well known. Much research focused on the role of plant food in health maintenance and prevention of chronic disease [1,2]. Food waste products derived from food processing are still quite rich in interesting bioactive compounds, which could be extracted and used to produce nutraceutical supplements and cosmetic products [3]. Hazelnuts represent an interesting source of by-products, producing a big amount of waste material such as leafy covers, skins, and shells. Hazelnuts are typically consumed whole or used as an ingredient in many processed foods. The study of their composition has gained attention with the aim to add economic value to waste from hazelnut processing [4,5,6,7]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
