Abstract
The present study was designed to evaluate the antidiabetic and antioxidant effect of Hibiscus rosasinensis against streptozotocin induced diabetic rats. Streptozotocin (STZ) was administered as a single dose (40 mg/kg) to induce diabetes. The hypoglycemic activity of Hibiscus rosasinensis extract (HRSEt) was investigated in a dose dependent manner such as (125, 250 and 500 mg/kg bwt) by evaluating various biochemical parameters. The levels of blood glucose, carbohydrate metabolizing enzymes, TBARS, enzymatic and non-enzymatic antioxidants and lipid profiles were found to be significantly increased in diabetic rats when compared to control groups. Administration of extract in the treated groups showed altered changes in the above mentioned parameters and found that among the three doseses, 250 mg/kg showed best result when compared to other two doses. HRSEt possess antioxidant, hypoglycemic and hypolipidemic activity against streptozotocin induced diabetic rats. However the detailed mechanism(s) of action will require elucidating in further studies.
Highlights
Diabetes mellitus is a group of metabolic disease characterized by chronic hyperglycemia resulting from defects in insulin secretion, insulin action or both
Changes in the body weight, blood glucose and plasma insulin concentrations of rats fed with Hibiscus rosasinensis and streptozotocin are presented in Tab. 1
There was an increased in the bodyweight and plasma insulin in control rats and rats fed with the extracts while there was a decreased in the body weight of rats treated with STZ
Summary
Diabetes mellitus is a group of metabolic disease characterized by chronic hyperglycemia resulting from defects in insulin secretion, insulin action or both. The abnormalities in carbohydrate, fat and protein metabolism that are found in diabetes are due to deficient action of insulin on target tissues (Craig et al, 2009). The prevalence of diabetes is rapidly rising all over the world. Current estimates are that there are at least 150 million people living with diabetes worldwide of which two-thirds are in developing countries. The total number of people with diabetes is predicted to rise above 300 million by 2025 (Sicree et al, 2006). Induced models have gained widespread acceptance for pathogenesis and drug screening research due to their rapid induction of diabetes. STZ is a commonly used chemical to generate diabetic animals in the laboratory for its ability to destroy insulin producing β-cells (Tjalve, 1983)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
