Abstract
The current work reports a simple and cost-effective green method for fabricating MEL@Fe3O4NPs and GA/Ag–Fe3O4@MEL-NCs using microbial glycolipid mannosylerythritol lipids (MEL) and gum arabic. The prepared bionanocomposites were characterized using X-ray diffraction analysis (XRD), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDS), and Fourier-transform infrared spectroscopy (FTIR). TEM analysis of the bionanocomposites showed the spherical shape particles. Furthermore, the GA/Ag–Fe3O4@MEL-NCs showed potent antioxidant efficacy against DPPH, ABTS, and FRAP (IC50; 62.95, 70.63, and 63.26 µg/mL, respectively). Moreover, the IC50 values of biosynthesized MEL@Fe3O4 and GA/Ag–Fe3O4@MEL-NCs for inhibition human liver cancer cells were 119.35 and 85.18 µg/mL, respectively, indicating its greater efficacy in killing cancer cells. As-prepared GA/Ag–Fe3O4@MEL-NCs may have great potential application in the field of pharmaceuticals as nanoantioxidants and anti-hepatocarcinoma.
Published Version
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