Abstract
Sixteen compounds were extracted and purified from the leaves of Liriodendron tulipifera. These compounds include aporphines, oxoaporphine, coumarin, sesquiterpene lactone, benzenoids, cyclitol and steroids. (+)-Norstephalagine (2) (an aporphine) and scopoletin (8) (a coumarin) were isolated from Liriodendron tulipifera leaves from the first time. The identified compounds were screened for their antiradical scavenging, metal chelating and ferric reducing power activities. The results have showed that these compounds have antioxidative activity. The study has also examined the chemopreventive property of the isolated compounds against human melanoma cells A375. The results shown that (−)-anonaine (1), (−)-liridinine (3), (+)-lirinidine (6), lysicamine (7) and epitulipinolide diepoxide (9) significantly inhibited the proliferation of melanoma cells. These results revealed that these compounds have antioxidative activity and chemopreventive activity in skin melanoma cells.
Highlights
Free radicals and reactive oxygen species (ROS) are formed of hydrogen peroxide or superoxide anions [1]
We have found a lot of phytochemicals from different plants with antioxidative activity and chemotherapeutic activity [8,9,10,11]
One study has shown that the bark and leaves extracts from L. tulipifera have antiplasmodial activity [21]
Summary
Free radicals and reactive oxygen species (ROS) are formed of hydrogen peroxide or superoxide anions [1]. The antioxidant and anticancer activities of bark extracts of L. tulipifera were examined in previous studies [9,10]. We describe the isolation and characterization of several compounds from the leaves of L. tulipifera. These compounds are (−)-anonaine (1), (+)-norstephalagine (2), (−)-liridinine (3),. (+)-Norstephalagine (2) (an aporphine) and scopoletin (8) (a coumarin) were first isolated from the leaves of this species. The study evaluates the antioxidant activity and anticancer activity of this species. To the best of our knowledge, this is the first study on investigating the antioxidant capacity and anticancer activities of scopoletin and (+)-norstephalagine from L. tulipifera
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