Abstract
Fifteen compounds were extracted and purified from the leaves of Nelumbo nucifera Gaertn. cv. Rosa-plena. These compounds include liriodenine (1), lysicamine (2), (−)-anonaine (3), (−)-asimilobine (4), (−)-caaverine (5), (−)-N-methylasimilobine (6), (−)-nuciferine (7), (−)-nornuciferine (8), (−)-roemerine (9), 7-hydroxydehydronuciferine (10) cepharadione B (11), β-sitostenone (12), stigmasta-4,22-dien-3-one (13) and two chlorophylls: pheophytin-a (14) and aristophyll-C (15). The anti-oxidation activity of the compounds was examined by antiradical scavenging, metal chelating and ferric reducing power assays. The results have shown that these compounds have antioxidative activity. The study has also examined the antiproliferation activity of the isolated compounds against human melanoma, prostate and gastric cancer cells. The results shown that 7-hydroxydehydronuciferine (10) significantly inhibited the proliferation of melanoma, prostate and gastric cancer cells. Together, these findings suggest that leaves of Nelumbo nucifera Gaertn. cv. Rosa-plena are a good resource for obtaining the biologically active substances with antioxidant properties.
Highlights
Nelumbo nucifera Gaertn, called lotus, is a perennial aquatic crop grown and widely distributed inAsia and some countries in Africa [1]
The results were expressed as the average of the mean values ± standard deviation (SD), and statistical comparisons were carried out using one-way analysis of variance (ANOVA)
The damage to cells caused by free radicals may play a role in the development of cancer and other diseases
Summary
Nelumbo nucifera Gaertn, called lotus, is a perennial aquatic crop grown and widely distributed in. Previous studies have shown that aporphine alkaloids from the leaves of Nelumbo nucifera Gaertn have many pharmacological properties such as anti-diabetic, anti-obesity, anti-hyperlipidemic, anti-oxidant, and anti-HIV activities [2,3,4,5,6,7]. Rosa-plena is very similar to Nelumbo nucifera Gaertn. Plants possess active ingredients with many non-vitamin antioxidants that can prevent ROS production [12]. In a previous study we have shown that aporphine derivatives in a leave extract of N. nucifera Gaertn. We describe the isolation and characterization of several compounds from the leaves of N. nucifera Gaertn. These compounds are aporphine alkaloids: liriodenine (1) [14], lysicamine (2) [14], (−)-anonaine (3) [14], (−)-asimilobine (4) [15], (−)-caaverine (5) [16],. We have found no publications concerning the anti-oxidant activity of the chemical components of this plant or their activity against cancer cell growth, so the objective of the present study was to investigate the anti-oxidative and anti-cancer activity of these compounds
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