Abstract
Antioxidant activities of wampee peel extracts using five different solvents (ethanol, hexane, ethyl acetate, butanol and water) were determined by using in-vitro antioxidant models including total antioxidant capability, 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging activity, reducing power, and superoxide scavenging activity. Ethyl acetate fraction (EAF) exhibited the highest antioxidant activity compared to other fractions, even higher than synthetic antioxidant butylated hydroxyl toluene (BHT). In addition, the EAF exhibited strong anticancer activities against human gastric carcinoma (SGC-7901), human hepatocellular liver carcinoma (HepG-2) and human lung adenocarcinoma (A-549) cancer cell lines, higher than cisplatin, a conventional anticancer drug. The total phenolic content of wampee fraction was positively correlated with the antioxidant activity. This is the first report on the antioxidant and anticancer activities of the wampee peel extract. Thus, wampee peel can be used potentially as a readily accessible source of natural antioxidants and a possible pharmaceutical supplement.
Highlights
In recent years, more interest has been paid to protect foods and human beings against oxidative damage caused by free radicals like hydroxyl, peroxyl, and superoxide radicals
This study investigated the antioxidant and anticancer activities of the wampee peel extracts and demonstrated the potent bioactivities of the extracts suitable to be used as natural antioxidant compounds or pharmaceutical supplements
Application of different solvents to extract antioxidant and anticancer compounds from wampee peel was investigated
Summary
More interest has been paid to protect foods and human beings against oxidative damage caused by free radicals like hydroxyl, peroxyl, and superoxide radicals. One possible solution is to explore the potential antioxidant and anticancer properties of plant extracts or isolated products of plant origin [1]. It is well known that many polyphenolic compounds, such as phenolic acids, flavonoids, anthocyanidins, and tannins, which possess remarkable antioxidant and anticancer activities, are rich in plant materials. Many polyphenolic compounds have shown many health-benefiting bioactive properties, such as antioxidant, anticancer, antiviral, antiinflammatory activities, and an ability to inhibit human platelet aggregation [4,5,6]. This study investigated the antioxidant and anticancer activities of the wampee peel extracts and demonstrated the potent bioactivities of the extracts suitable to be used as natural antioxidant compounds or pharmaceutical supplements
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