Antioxidant and Antibacterial potential of Lycium shawii Roem. and Schult (Awsaj) and Tetraena qatarensis (Hadidi) Beier and Thulin leaves: A Herbal approach to Combat Drug Resistance and Oxidative Stress

Abstract

The present investigation deals with the antioxidant and antibacterial activity of chloroform and methanolic extracts of Lycium shawii and Tetraena qatarensis leaves. Antioxidant activity was evaluated using DPPH and FRAP assay. In the DPPH assay, the lowest IC50 values 45.63 and 46.17µg/ml were observed with methanolic and chloroform extract Lycium shawii leaves, respectively. In FRAP assay most of the extracts showed optical density >0.5 at 40µg/ml. In the antibacterial activity test, all tested extracts were found active towards all bacterial strains with MIC ranged between 0.03125 to 0.12mg/mL. Subsequently, in the combined effect assay, the highest fold increase (92.31%) was observed against Salmonella typhi with methanol extract of Lycium shawii leaves. The examined plants could be used as a treatment for microbial infection and oxidative stress after detailed follow-up investigations.