Abstract
Exposure to lead (Pb), a toxic heavy metal produces a wide range of adverse health effects. Both adults and children can suffer from the effects of Pb-poisoning, but childhood Pb-poisoning is much more frequent. Low-level Pb-exposure can result in reduced IQ, learning disabilities, attention deficit disorders, behavioural problems, stunted growth, impaired hearing, and kidney damage. Oxidative stress is proposed as an intracellular mechanism in Pb-induced toxicity, suggesting the fact that antioxidants might play a very important role in the treatment of Pb-poisoning. The present study was designed to investigate whether fraxetin (FXT), an important coumarin has a beneficial effect on human SH-SY5Y neuroblastoma cells exposed to Pb. In the present study, the cells were exposed to different concentrations (0.01-10 mM) of Pb for 48 hours to determine the concentration (IC50 = 5 mM) at which 50% inhibition in the viability of cells.
Highlights
Environmental exposure of Lead (Pb) may leads to alterations in the health aspects [1,2] of a normal human being
School age group children are the most affected group of population because of their growing stage of life associated with developmental progress of nervous system and parts of the brain, which lead to the behavioural changes, learning disabilities, reduced IQ, stunted growth, hearing problems and even pathology associated with kidney dysfunction [9]
To examine the effects of FXT (0-100 mM) alone, the cells were treated for 48 hours with different concentrations of fraxetin
Summary
Environmental exposure of Lead (Pb) may leads to alterations in the health aspects [1,2] of a normal human being. Brain is the most affected tissue due to the toxicity being generated by Pb [7]. Neuronal toxicity associated with memory, cognitive dysfunction, aggressive behaviour and lack of attention [8] are the typical characteristics of the Pb induced toxicity. School age group children are the most affected group of population because of their growing stage of life associated with developmental progress of nervous system and parts of the brain, which lead to the behavioural changes, learning disabilities, reduced IQ, stunted growth, hearing problems and even pathology associated with kidney dysfunction [9]. Increased exposure of Pb may leads to mental retardation, numbness, changes in the impulse, often ends with death, alterations in the blood pressure, imbalance in the fetal growth, issues associated with pain in the joints and irritation
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