Abstract
In this study, the antioxidant and anti-wrinkling effects of fraction from Vitex trifolia L. were investigated. Among the fractions, ethyl acetate fraction showed the highest antioxidant activities in 1-1-diphenyl-2-picryl-hydrazyl, 2,2’-Azino-bis(3-ethylbenz othiazoine-6-sulfonic acid radical scavenging and elastase inhibition with 76, 89, and 74%, respectively, at a concentration of 1,000 μg/mL. This fraction, at the concentration of 25 μg/mL, inhibited 70% fibroblast cell viability and 86% the matrix metalloprotease (MMP)-1. In addition, the results from Western blot assay showed that this fraction (25 μg/mL) expressed the MMP-1 protein level by decreasing 50%. The findings suggest that the ethyl acetate fraction from V. trifolia has great potential as a cosmeceutical ingredient with antioxidant and anti-wrinkle effects.
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