Abstract
Background: According to recent studies, reactive oxygen is the leader of human metabolic disease development. The use of natural antioxidants is the best way to stop or prevent this problem. Therefore, the aim of this study was to evaluate the antioxidant and anti-inflammatory activities and to determine the polyphenolic contents of the Bidens engleri and Boerhavia erecta fractions. Methods: Plant fractions were obtained using Soxhlet procedures with hexane, dichloromethane, acetonitrile, ethyl acetate, methanol, and butanol solvent, successively. The different fractions were compared according to their antioxidant, anti-inflammatory activities, total phenolic, and total flavonoid contents. The phenolic contribution to the biological activity was evaluated. Result: The Bidens engleri and Boerhavia erecta fractions showed the highest antioxidant abilities, notably the polar fractions, which inhibited significantly the radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2-O-azinobis(3-ethylbenzoline-6-sulphonate) (ABTS). The butanol fraction from Bidens engleri and methanol fraction from Boerhavia erecta have presented the best iron (III) reduction power with 211.68 and 198.55 mgAAE/g, respectively. Butanol and acetonitrile were the best solvents for extracting phenolic compounds from Bidens engleri and Boerhavia erecta, respectively. In contrast, dichloromethane was the best solvent for extracting a flavonoid from two plants with anti-COX-2 and anti-LOX-15 active compounds. The phenolic compound contributed significantly to antioxidant activity (r > 0.80). Conclusion: The Bidens engleri and Boerhavia erecta fractions possessed a potential antioxidant for fighting oxidative stress and helping to prevent diabetes, hypertension, and cardiovascular diseases. The uses of this plant could be promoted in Burkina Faso.
Highlights
IntroductionIt was demonstrated that reactive oxygen species (ROS) and reactive nitrogen species (RNS) played an important role in human disease development [1]
Oxidative stress is an inevitable consequence of life in an oxygen-rich atmosphere.The environment is filled with a lot of reactive oxygen species (ROS) and reactive nitrogen species (RNS).In recent data, it was demonstrated that ROS and RNS played an important role in human disease development [1]
It was demonstrated that ROS and RNS played an important role in human disease development [1]
Summary
It was demonstrated that ROS and RNS played an important role in human disease development [1]. In Burkina Faso, some recent studies have shown some alarming data concerning the prevalence of metabolic diseases [2]. The oxidative stress plays a direct or indirect role in the Medicines 2018, 5, 53; doi:10.3390/medicines5020053 www.mdpi.com/journal/medicines. Medicines 2018, 5, 53 pathophysiology of diseases, such as cancer, diabetes, and cardiovascular diseases [3,4]. The intake of natural antioxidants has been reported to reduce the risk of cancer, cardiovascular diseases, diabetes, and other diseases that are associated with aging [5,6]. Reactive oxygen is the leader of human metabolic disease development. The aim of this study was to evaluate the antioxidant and anti-inflammatory activities and to determine the polyphenolic contents of the Bidens engleri and Boerhavia erecta fractions
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