Abstract
This study investigated the anti-growth and antioxidant properties of four plant species native to the Anatolian region: Heracleum humile, Doronicum reticulatum, Centaurea drabifolia, and Senecio olympicus. Plant materials were collected, authenticated, and extracted using a Soxhlet apparatus. The growth inhibitory activities of the extracts were evaluated in human breast cancer cell lines MCF-7 and MDA-MB-231, and the nonmalignant immortalized human breast cell line MCF-10A, using the sulforhodamine B (SRB) assay. Antioxidant capacities were assessed via DPPH and CUPRAC assays. The results demonstrated that C. drabifolia extract exhibited potent cytotoxic effects, while D. reticulatum displayed selective toxicity and the most pronounced antioxidant activity among the evaluated species. These findings contribute to our understanding of the therapeutic potential of these indigenous plant species in addressing various public health issues, including cancer.
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