Abstract
The aim: to study the antioxidant and anticytolytic activity of the parsnip herb thick extract (PHTE) in conditions of catecholamine myocardial dystrophy in rats.
 Materials and methods. Catecholamine myocardial dystrophy was reproduced in rats by a single subcutaneous injection of 0.18 % adrenaline hydrochloride solution at a dose of 0.5 mg/kg (0.28 ml/kg) of body weight. The experiment used 36 white male rats with an initial weight of 220–250 g, 4–4.5 months of age. The tested drugs were PHTE at doses of 100 and 200 mg/kg and the reference drug (RD) “Tricardin” were administered intragastrically in a therapeutic and prophylactic regimen for 7 days, the last time on the day of the experiment 1 hour before the administration of cardiotoxin. The activity of the studied agents was assessed by the survival rate of the animals, the functional state of the myocardium (ECG studies), by the effect on the heart mass ratio (HMR), the activity of aspartate aminotransferase (ASAT), the level of active products interacting with thiobarbituric acid (TBA-AP) and the content of reduced glutathione (RG) in the heart homogenate.
 Results. The study of the effect of PHTE on the lipid peroxidation / antioxidant protection (LPO / AOP) system showed that a pronounced antioxidant effect of the tool was found at a dose of 200 mg/kg: there was an increase in VG at the trend level (0.05<p<0.10) and a significant decrease (p<0.05) the content of TBK-AP in 1.85 times compared with the group of positive control (PC). A similar effect was found in the comparison drug “Tricardin”. PHTE at a dose of 100 mg/kg was less influential. The use of PHTE in both doses and the comparison drug “Tricardin” reduced the severity of cytolytic processes: the activity of the enzyme AST – a marker of cardiocytolysis, was lower than in the PC group. PHTE at doses of 100 and 200 mg/kg contributed to a certain normalization of some ECG parameters compared to PC: a slight insignificant decrease in heart rate and a significant decrease (p<0.05), QT interval, systolic index (SI) and decreased ischemia marker – ST segment displacement. The comparison drug "Tricardin" showed a similar effect to PHTE on the functional state of the myocardium in adrenaline intoxication.
 Conclusions. Parsnip herb thick extract exhibits antioxidant and anticytolytic activity, improves the functional state of the myocardium, prevents a decrease in the severity of alterative processes in the organ under conditions of adrenaline myocardial dystrophy
Highlights
Cardiovascular diseases occupy a leading position in terms of mortality among other diseases
According to the data (Table 3), it could be argued that the surviving positive control (PC) animals developed myocardial infarction, characterized by changes in many indicators of the cardiovascular system, determined by ECG 24 hours after the initiation of pathology
The development of cytolytic processes in the myocardium of PC rats was accompanied by a significant increase in 1.62 times the level of the marker enzyme cytolysis AST in the serum relative to group intact control (IC) (Table 3)
Summary
Cardiovascular diseases occupy a leading position in terms of mortality among other diseases. In the genesis of their development, an important place is given to stress as a risk factor, the initiation of which involves the pathogenic effects of catecholamines, namely adrenaline [1, 2]. Adrenaline has both a direct negative effect on the myocardium and mediated by significant metabolic disorders, which leads to irreversible damage to cardiomyocytes [3, 4]. Against the background of LPO intensification in the myocardium, cytolytic processes are intensified, which leads to cardiac dysfunction. Determinant under such conditions is the state of the antioxidant system that counteracts the processes of LPO [6, 7]
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