Abstract
Eimeriosis is caused by a protozoan parasite of the genusEimeria and infection affecting most domestic animal species. The aim of this research was to comprehend the impact of selenium nanoparticles (SeNPs) on eimeriosis induced by Eimeria papillata in mouse jejunum, and how they work as antioxidants and anti-apoptotic agents against eimeriosis. The numbers of meronts, gamonts, and developing oocysts of E. papillata reduced after the infected mice were treated with the SeNPs. The levels of malondialdehyde (MDA), nitric oxide (NO), and other oxidative stress-related molecules, such as glutathione (GSH), catalase (CAT), and superoxide dismutase (SOD), were assayed. E. papillata was able to change the redox status of the jejunal cells; this was confirmed by the elevation of the MDA and NO levels, and the decrease of the GSH levels and the activities of the antioxidant enzymes CAT and SOD. SeNP treatment significantly reversed this disturbance of the redox status. The expression levels of the apoptotic markers Bax and caspase-3 in the jejunal samples were evaluated using qRT-PCR. The SeNPs decreased the Bax and caspase-3 expression after being administered to the E. papillata-infected mice. Collectively, the SeNPs demonstrated antioxidant and anti-apoptotic activities against murine eimeriosis.
Highlights
Eimeriosis is one of the most dangerous poultry diseases around the world (Ola-Fadunsin & Ademola 2013)
The efficient dose of the selenium nanoparticles (SeNPs) used in this research was the same as the dose used in our prior research (0.5 mg/ kg); we investigated the role of SeNPs against apoptotic changes in mouse jejunum and the oxidative damage caused by E. papillata infection
This study demonstrated that SeNPs show anti-coccidial, antioxidant, and anti-apoptotic activities during E. papillata infection
Summary
Eimeriosis is one of the most dangerous poultry diseases around the world (Ola-Fadunsin & Ademola 2013). This parasitic disease, which is caused by coccidian parasites belonging to the genus Eimeria, induces problems for the poultry industry (Lawal et al 2016). Diarrhea, and dehydration are the common clinical signs after the infection (Mehlhorn 2014). This disease has led to a global annual loss of about $3 billion USD for the poultry industry (Blake & Tomley 2014).
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