Antioxidant and alpha-amylase inhibitory potentials of Cocos nucifera husk.

Hamdalat Folake Muritala,Sarah Abimbola Akande,Abdulkabir Bolakale Bello,Jubril Olayinka Akolade,Azeemat Titilola Abdulazeez,Raliat Abimbola Aladodo

doi:10.1002/fsn3.741

Hamdalat Folake Muritala, Sarah Abimbola Akande + Show 4 more

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https://doi.org/10.1002/fsn3.741

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Abstract

Concoctions containing extract from Cocos nucifera husk fiber are used in Nigeria by traditional medicine practitioners for management of diabetes and its associated complications. Preliminary antidiabetic study was designed to validate the folkloric usage of the plant extract. Dried coconut husk fiber was pulverized and extracted with methanol, followed by partitioning of the methanolic extract in ethyl acetate. Phenolic content, radical scavenging activity and antioxidant capacity as well as inhibitory effects of C. nucifera methanolic (CN‐M) extract and its ethyl acetate (CN‐E) fraction on pancreatic α‐amylase and lipid peroxidation were determined. Total phenolic content and antioxidant capacity of CN‐E fraction were significantly higher than that of CN‐M extract, whereas there was no significant difference in their ability to scavenge free radicals. The CN‐E fraction also exhibited higher in vitro and in vivo inhibitory effects on α‐amylase activity and lipid peroxidation; reducing blood glucose level within 5 days following intraperitoneal administration of the C. nucifera extract to alloxan‐induced hyperglycemic rats. The phenolic‐rich extracts from coconut husk can be further explored as nutraceutical supplement in food formulation for diabetic patients.

Highlights

Traditional medicine employs the use of natural products for the management of noncommunicable diseases such as diabetes, cardiovascular and inflammatory diseases, due to the high cost of available orthodox therapy and adverse effect of synthetic drugs
In north central Nigeria, personal communication with traditional medicine practitioners (TMPs) revealed that diabetic diets are formulated with extracts from the dried husk of Cocos nucifera
| 1681 phenolic content quantified in C. nucifera methanolic extract and its ethyl acetate fraction compared favorably with the amount determined in previous studies (Bezerra dos Santos Oliveira et al, 2013; Khonkarn, Okonogi, Ampasavate, & Anuchapreeda, 2010; Lima et al, 2016)

Summary

Introduction

Traditional medicine employs the use of natural products for the management of noncommunicable diseases such as diabetes, cardiovascular and inflammatory diseases, due to the high cost of available orthodox therapy and adverse effect of synthetic drugs. In north central Nigeria, personal communication with traditional medicine practitioners (TMPs) revealed that diabetic diets are formulated with extracts from the dried husk of Cocos nucifera (coconut). Research studies have reported analgesic and anti-inflammatory activities (Dua et al, 2013), antimicrobial and antiviral (Esquenazi et al, 2002). Antidiabetic properties of different part of the plant such as the water, oil, and fruit juice have been reported in literature (Mohammed & Luka, 2013; Naskar et al, 2011)

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