Abstract
The whole plant of the methanolic extract from Leucas cephalotes was screened for invitro antioxidant (using the DPPH method), invivo analgesic (using hot plate test in mice) and anti-inflammatory (using rat paw edema test) activities. The methanolic extract of Leucas cephalotes (MELC) scavenged the DPPH radicals in a dose-dependent manner. The IC50 value to scavenge DPPH radicals was found to be 421.3µg/ml. A significant (p<0.0005) analgesic activity was observed at 60 min with 200 mg/kg, and 400 mg/kg exhibited maximum activity. The maximum anti-inflammatory response was produced at 3 hr and 2 hr with doses of 200 and 400 mg/kg, respectively. These results suggest that the methanolic extract from Leucas cephalotes exerts significant analgesic and anti-inflammatory effects, which were comparable with standard drugs.
Highlights
Diphenyl Picryl Hydrazyl (DPPH) radical was used as a substrate to evaluate the free radical scavenging activity of metanólico de Leucas cephalotes (MELC) extract
The reduction capability of DPPH radicals was determined by the decrease in its absorbance at 517 nm, which is induced by antioxidants
DPPH is often used as a substrate to evaluate antioxidant activity of MELC extract
Summary
The plant is known as “Dronapushpi in Sanskrit and Peddatumni in telugu by Indians”(Parrotta et al, 2001). The whole plant was used to treat bronchitis, inflammation, asthma, dyspepsia, paralysis and skin diseases. Y.N. Reddy , G.K. Mohan al.,1990), 7 alpha-hydroxystigmasterol (Miyaichi et al, 2006), stigmasterol (Kolak et al, 2005) , 5-hydroxy-7, 41-dimeathoxyflavone (Gonzalez et al.,1989), gonzalitosin (Dominguez et al.,1976), tricin (Fujii et al, 1995) and apigenin 7-0-β-D-(6-O-p-coumaroyl) glucopyranoside (Itokawa et al.,1981).The aim of the present study was to evaluate the In vitro anti-oxidant, In vivo analgesic and anti inflammatory activities of the methanolic whole plant extract of Leucas cephalotes (MELC)
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