Abstract
We report the synthesis of aramide nanoparticles containing a chiral N-phthaloyl valine moiety and their antioxidant activities on hepatic contents of cytochrome P450, amidopyrene N-demethylase, aniline-4-hyroxylase and induced the hepatic content of cytochrome b5 and nicotinamide adenine dinucleotide phosphate (NADPH) cytochrome C-reductase. Polymers were obtained as well-separated spherical nanoparticles while highly aggregated particles via H-bonding organization of the aramide-containing pyridine led to a thin layer formation. The effects of the nanoparticles and CCl4 on enzyme activities and thiobarbituric acid reactive substances (TBARS) levels of male rat liver were studied. Pretreatments of rats with the polyamides prior to the administration of CCl4 decreased the hepatic content of the tested enzymes. Doses reduced the toxic effects exerted by (•CCl3) upon the liver through inhibition of the cytochrome P450 system. Inhibition of such metabolizing enzymes could reduce the carcinogenic effects of chemical carcinogens.
Highlights
The liver plays a major role in regulating various physico-chemical functions of the body, including synthesis, secretion and metabolism of xenobiotics
We describe for the first time the synthesis and characterization of nanoscale aramides containing N-phthaloyl valine moieties in the side chain by a precipitation polymerization method [25,26,27]
Recent advances in asymmetric reactions and catalysis as well as in chiral separations have afforded a rapid increase in the number of commercially available optically active compounds and reagents [32,33] and the simplest method of synthesizing optically active polymers involve the polymerization of optically active monomers
Summary
The liver plays a major role in regulating various physico-chemical functions of the body, including synthesis, secretion and metabolism of xenobiotics. The trichloromethyl radical can react with oxygen to form the peroxy trichloromethyl free radical (CCl3O2), which is more reactive than the (CCl3) and produces similar kinds of damage
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