Abstract
Prolonged exposure to dioxin can lead to negative effects. Oxidative stress is caused by dioxin toxicity due to interference of the metabolism process including lipid metabolism. This current study was to address the role of casein yogurt in the prevention of oxidative stress caused by dioxin intoxication. Substances used were 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) diluted in corn oil and casein from goat milk yogurt. A total of 24 Wistar rats divided into 6 groups: control, placebo with 600 mg/kg BW of casein, TCDD group with 100 ng/kg BW of TCDD, T1 to T3 groups were given with TCDD and casein in different dose: 300, 600, and 900 mg/kg BW. The respective dose was given orally daily for 21 days. Blood serum was collected for cholesterol and triglyceride analysis. Liver samples were collected for superoxide dismutase (SOD) activity assay. Statistic analysis using one-way ANOVA and post hoc Tukey test. Results showed that casein yogurt increased SOD activity in TCDD intoxicated rats. A significant increase (P<0.05) was shown by the group with 600 and 900 mg/kg BW of casein. Serum lipid profile exhibited no significant change in serum cholesterol and triglyceride level. Casein yogurt is potential to prevent cellular damage caused by dioxin toxicity.
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