Abstract
Soursop Leaves ( Annona muricata L.) and Tea Leaves ( Camellia sinensis ) are plants that contain flavonoids which are considered to act as antioxidants and can become chemopreventive agents. This study aims to identify the potential of Soursop Leaves and Tea Leaves as chemopreventive agents. The first stage of this research was to determine the presence of flavonoids in both of ethanolic extract using TLC method. The second stage is to examine the antioxidant activity of the combination of ethanolic extract of soursop leaves and tea leaves against free radical DPPH (1,1-diphenyl-2-pikrihidrazil). Docking molecular test of acetogenin and catechin compounds at HER-2 and ER-α receptors which are biomarkers of breast cancer. Furthermore, the optimization of effervescent granule production using moist granulation method is carried out. The result shows that ethanolic extract of soursop leaves and tea leaves contains flavonoid shown with Rf value of 0.66 and 0.68, and the comparison of Rf 0.66. The combination of both ethanolic extract has very strong antioxidant activity with IC 50 value 26,90 μg/mL. The result of molecular docking of acetogenin and catechin compounds at HER-2 receptors shows respective docking score of -6.3 kcal/mol and -6.7 kcal/mol while ER-α receptors shows a docking score of -6.5 kcal/mol and -7.6 kcal/mol. In addition, the most optimal effervescent granule production is formula four with physical test result such as moisture content of 1.07% with a dissolve time of 45.5 seconds and acidity of 6.18. The result shows that ethanolic extract of soursop leaf ( Annona muricata L.) and Tea Leaves ( Camellia sinensis ) have potential activity as chemopreventive agents and can be formulated into effervescent granule production.
Highlights
One of cancers that has the highest incidence rate in Indonesia is breast cancer, the new incidence rate of which reaches up to 43.3%
Tea leaves (Camellia sinensis) have many benefits, the biggest of which is as a powerful antioxidant as it contains catechin compound
This study aims to identify the potential antioxidant of a combination of Camellia sinensis and Annona muricata L. leaves and the optimization of its formulation into effervenscent granule production
Summary
One of cancers that has the highest incidence rate in Indonesia is breast cancer, the new incidence rate of which reaches up to 43.3%. Breast Cancer is a type of cancer that ranks first in women. It usually attacks women over 50 years of age. 1. Tea leaves (Camellia sinensis) have many benefits, the biggest of which is as a powerful antioxidant as it contains catechin compound. Catechins are believed to be a powerful antioxidant that can suppress cell proliferation and have a chemo preventive effect. Soursop leaves (Annona muricata L.) have been shown to have anticancer effects. This study aims to identify the potential antioxidant of a combination of Camellia sinensis and Annona muricata L. leaves and the optimization of its formulation into effervenscent granule production
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