Abstract
The aim of this study is to investigate in vitro antioxidant activities and the phytochemical screening endophytes. Seven different endophytic fungi were isolated from different parts of the plant and their extracts subjected to know antioxidant properties and phytochemical screening. Phytochemical analysis revealed the presence of tannins, flavonoids, steroids, alkaloids, phenols and proteins from different solvents extracts of different endophytes. The antioxidant activity was evaluated by six separated methods: scavenging of free radical DPPH, FRAP, TBA, superoxide radical, FTC and iron methods. All seven different endophytes yielded almost all phytochemicals in methanol extracts which were tested. The endophytes A. niger, Penicillium sp. and Trichoderma sp. have shown potential in vitro antioxidant activities. Further work is needful to isolate the exact compound which is responsible for antioxidant activity and biophysical characterization will be done in the future.
Highlights
Tabebuia argentea (Bignoniacae) is a large and yellow flowering tree
The aim of this study is to investigate in vitro antioxidant activities and the phytochemical screening endophytes
The antioxidant activity was evaluated by six separated methods: scavenging of free radical DPPH, FRAP, Thiobarbituric Acid (TBA), superoxide radical, Ferric Thiocyanate (FTC) and iron methods
Summary
Tabebuia argentea (Bignoniacae) is a large and yellow flowering tree. Has proven to be rich source of many organic compounds, especially, of phenolic and poliophenolic nature. Such substances have been classified as cytotoxic, antimicrobial and antifungal [1,2] by the presence of anthroquinone compounds. Many natural naphthoquinone and lapachol have extensively been used to control cancer and they have ability to interfere with topoisomerase enzymes, which are critical for DNA replication in cells [3]. The antitumor activity of lapachol may be due to its interaction with nucleic acids and the interaction of the naphthoquinone moiety between base pairs of the DNA helix occurs with subsequent inhibition of DNA replication and RNA synthesis [4]. Other biological activities of lapachol are antimetastatic activity [5], antimicrobial and antifungal activity [6], antiviral activity [7], anti-inflammatory [8], antiparasitic activity [4], leishmanicidal activity [9] and molluscicidal activity [10]
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