Abstract
Antioxidant Activity and Lipoxygenase Enzyme Inhibition Assay with Total Flavonoid Content from Garcinia hombroniana Pierre Leaves
Highlights
Previous research has been conducted on the bark of G. hombroniana Pierre which showed that the ethyl acetate extract had the highest content of flavonoid and antioxidant activity EC50 values obtained by FRAP method is 5579.8 ± 117.7 mol TE (Trolox Equivalent)/g
This study aims to determine antioxidant activity tested by using FRAP (Ferric Reducing Antioxidant Power) method and inhibition of lipoxygenase activity of G. hombroniana leaves extract
Analysis by TLC (Thin Layer Chromatography) gave the result that ethyl acetate extract of the leaves of G. hombroniana has the highest content of flavonoid
Summary
Plants contain various chemical compounds such as phenolic, flavonoid, carotenoid, steroid, and thiol compound that may help protect cells from oxidative stress damage and reduce the risk of chronic disease. Flavonoid such as catechin and epicatechin can be used for the activity of antioxidant and anti-inflammatory.[1]. This research is expected to provide information on the strength of antioxidant activity and inhibition of lipoxygenase activity in the most active extract of n-hexane, ethyl acetate, and methanol leaves of G. hombroniana Pierre as a source of antioxidant and anti-inflammatory
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